Ian Sokoliwski wrote:
In fact, if you are painting stuff for the web, converting from CMYK to RGB (for .jpgs and .gif's) also creates a colour shift, but a very minor one compared to RGB to CMYK.
This is because the gamut of most RGB color spaces are larger than most CMYK gamuts -- though often CMYK can produce reds and yellows that RGB cannot reproduce, RGB produces blues and greens that are completely out of CMYK's capability to reproduce.
This is because RGB is color based on projected light, based on the (theoretically) 256 shades of grey produced by a monitor, television screen, or scanner, whereas CMYK is based on reflected light and therefore is often limited by the medium on which it is printed, the inks used, and so on.
Guess who does color separation work for a printer for a living?
Oh, and to answer the original post's question, I do everything in layers.